Search Result
Results for "
peptide substrate
" in MedChemExpress (MCE) Product Catalog:
5
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P1344A
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DAPK
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Cancer
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DAPK Substrate Peptide TFA is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM .
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- HY-P3815
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Casein Kinase
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Others
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Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide. Casein Kinase 2 Substrate Peptide is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). Casein Kinase 2 Substrate Peptide can be used for protein kinase CK2 activity determination .
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-
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- HY-P3814
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Ribosomal S6 Kinase (RSK)
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Cancer
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S6 Kinase Substrate Peptide 32 is a substrate of Ribosomal S6 Kinase (RSK). S6 Kinase Substrate Peptide 32 can be used to measure the activity of RSKs which phosphorylate ribosomal protein S6 .
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-
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- HY-P2505
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Syk
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Others
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Syk Kinase Peptide Substrate is a Syk kinase peptide substrate.
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-
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- HY-P0141
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Akt
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Others
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Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or
MAPK1 .
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-
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- HY-P2504
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Syk
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Others
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Syk Kinase Peptide Substrate, Biotin labeled is a biotin-labled Syk kinase peptide substrate.
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-
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- HY-P0141A
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Akt
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Others
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Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .
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-
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- HY-P3818
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PKC
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Others
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PKCδ Peptide Substrate is an absolutely specific substrate for the δ-type of PKC, with a sequence corresponding to sequence 422-443 of murine eEF-1α and containing Thr-431 .
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-
-
- HY-P1113
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GSK-3
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Others
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Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .
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-
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- HY-P1113A
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GSK-3
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Others
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Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .
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-
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- HY-P3904
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Biochemical Assay Reagents
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Others
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P34cdc2 Kinase Substrate Peptide is a synthetic peptide substrates for P34 cdc2 kinase, with a Km of 74 μM for the purified human enzyme. P34cdc2 Kinase Substrate Peptide can be used in a rapid assay of P34 cdc2 phosphorylation in vitro. P34 cdc2, a protein serinehhreonine kinase, is a cell division cycle-regulated protein kinase .
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-
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- HY-P3921
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Casein Kinase
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Cancer
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Casein Kinase II Substrate is a casein kinase II (CK2) peptide substrate that can be selectively phosphorylated by CK2 .
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-
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- HY-P10163
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Fluorescent Dye
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Others
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α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm
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-
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- HY-P3920
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PKA
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Cancer
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Cys-Kemptide is a cysteine-terminated substrate peptide that can used to measure protein kinase A (PKA) activity .
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-
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- HY-P2162
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Myosin
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Cancer
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Kemptamide, a 13 amino acid fragment with a sequence corresponding to residues 11-23 of gizzard light chain. Kemptamide is a peptide substrate of myosin light-chain kinase (MLCK) .
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-
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- HY-P10082
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Caspase
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Others
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Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
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-
-
- HY-P3722
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Fluorescent Dye
MMP
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Others
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Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
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- HY-P3722A
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Fluorescent Dye
MMP
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Others
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Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE); ADAM17, ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
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- HY-P1486
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Endogenous Metabolite
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Cardiovascular Disease
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Angiotensinogen (1-14), human is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .
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- HY-P1486A
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Endogenous Metabolite
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Cardiovascular Disease
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Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .
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-
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- HY-P3940
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PKC
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Others
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Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .
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- HY-138126A
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Others
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Neurological Disease
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Dansyl-Tyr-Val-Gly TFA is a substrate of peptidylglycine monooxygenase (PHM). Peptidylglycine monooxygenase is an essential enzyme for the posttranslational amidation of neuroendocrine peptides .
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- HY-155667A
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Cathepsin
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Others
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Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
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- HY-P2842
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Others
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Others
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Aminopeptidase catalyzes the cleavage of amino acids from the amino terminus of protein or peptide substrates .
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- HY-155667
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Others
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Others
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Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
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- HY-P3791
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Fluorescent Dye
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Others
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N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
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-
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- HY-W324458
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Fluorescent Dye
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Others
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MCA succinimidyl ester is a derivative of MCA (HY-W027544). MCA succinimidyl ester has succinimidyl ester can react selectively with amines. MCA succinimidyl ester can be used as peptide substrate for fluorescence resonance energy transfer .
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- HY-P5915
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HIF/HIF Prolyl-Hydroxylase
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Cancer
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FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2, a 5-FAM labeled HIF-1α peptide, is a substrate of VHL. FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 binds to VHL protein with a KD of 3 nM. Ex/Em (λ) = 485/520 nm .
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-
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- HY-P1115
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Akt
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Others
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AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position .
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- HY-P1115A
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Akt
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Others
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AKTide-2T TFA is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T TFA mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position .
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- HY-P2295
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SARS-CoV
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Others
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Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .
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-
-
- HY-P4931
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Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
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MMP
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Cancer
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Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
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-
-
- HY-P1821
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MHP4-14
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PKC
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Neurological Disease
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Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca 2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .
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- HY-P1821A
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MHP4-14 TFA
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PKC
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Neurological Disease
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Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca 2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .
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- HY-P3944
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CaMK
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Neurological Disease
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Calmodulin Dependent Protein Kinase Substrate is a Ca 2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide substrate for protein kinases .
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- HY-P3943
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CaMK
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Neurological Disease
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Calmodulin Dependent Protein Kinase Substrate Analog is a Ca 2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide substrate for protein kinases .
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- HY-P3797
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Furin
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Cancer
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Furin Substrate is an peptide. Furin Substrate can be used for the research of various biochemical .
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-
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- HY-P10098
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PKA
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Cancer
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PKA Substrate is a potent and selective substrate peptide of PKA that can be used to detect PKA activity .
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- HY-P2547
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Src
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Others
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Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay .
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- HY-P5450
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PDK-1
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Others
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PDKtide is a biological active peptide. (This peptide is a substrate for PDK1 (Phosphatidylinositide-Dependent Kinase 1).)
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- HY-P10008
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Cathepsin
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Cancer
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Cathepsin D/E Substrate, Fluorogenic, 11 amino acid peptide, is a selective substrate for cathepsins D and E. Cathepsin D/E Substrate, Fluorogenic does not act as a substrate for cathepsins B, H, or L .
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- HY-P10036
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PKG
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Others
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G-Subtide is a G-substrate peptide localized in Purkinje cells of the cerebellum. G-Subtide has little activity distinct from background and is a preferentially phosphorylated peptide substrate of recombinant PfPKG2 protein .
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- HY-P1448
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-
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- HY-P3770
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PKC
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Others
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Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak PKC inhibitor .
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- HY-P5998
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Myosin
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Cancer
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Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate .
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-
-
- HY-P5939
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Angiotensin Receptor
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Cardiovascular Disease
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Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .
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-
-
- HY-P0136
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SAMS
2 Publications Verification
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AMPK
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Metabolic Disease
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SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
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-
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- HY-P4348
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Proteasome
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Others
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MeOSuc-Gly-Leu-Phe-AMC is a peptide substrate of proteasomal .
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-
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- HY-P4344
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MetAP
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Others
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Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .
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- HY-P4366
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- HY-P4390
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- HY-P1746
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PKC (19-31)
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PKC
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Inflammation/Immunology
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Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .
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- HY-P0320
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Phosphatase
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Others
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EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
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- HY-P0320A
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Phosphatase
Biochemical Assay Reagents
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Others
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EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
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- HY-P0320B
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Phosphatase
Biochemical Assay Reagents
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Others
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EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
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- HY-P2714
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- HY-P1746A
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PKC (19-31) (TFA)
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PKC
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Inflammation/Immunology
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Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .
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- HY-P1595
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PKA
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Metabolic Disease
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CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.
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- HY-P4338
-
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PAI-1
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Others
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Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .
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-
- HY-P4350
-
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Elastase
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Others
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Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like .
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- HY-P4471
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-
- HY-P2559
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CDK
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Cancer
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CDK7/9 tide is peptide substrate for CDK7 or CDK9 .
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- HY-P2558
-
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GSK-3
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Others
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GSK3 Substrate, α, β subunit is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used to measure GSK-3 activity .
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-
- HY-153859
-
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Others
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Others
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Ser-SNAC TFA is a small-molecule substrate for NRPS C domains. As for NRPSs, refers to nonribosomal peptide synthetases, are large multidomain proteins to catalyze the formation of biologically active natural products. Ser-SNAC TFA can be used for characterizing the substrate specificity of C domain-catalyzed peptide bond formation .
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- HY-148372
-
-
- HY-P4359
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PIN1
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Others
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Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .
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- HY-P10060
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- HY-P1576A
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- HY-P4490
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- HY-P4346
-
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Elastase
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Others
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MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases .
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- HY-P4388
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SARS-CoV
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Infection
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Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL pro .
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- HY-P1883
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Fluorescent Dye
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Infection
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Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
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- HY-P5440
-
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ERK
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Others
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ERKtide is a biological active peptide. (ERKtide is a peptide substrate for ERK2. Extracellular regulated protein kinase 2 (ERK2) is a eukaryotic protein kinase whose activity is regulated by mitogenic stimuli.)
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-
- HY-P1595A
-
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PKA
|
Metabolic Disease
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CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a PKA substrate .
|
-
- HY-P1883A
-
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Fluorescent Dye
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Infection
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Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
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- HY-P0315
-
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Akt
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Others
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Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.
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- HY-P0291
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PKA
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Others
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Kemptide (Phospho-Ser5) is a phosphate acceptor peptide that serves as a specific substrate for cAMP-dependent protein kinase (PKA).
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- HY-P3748
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Casein Kinase
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Others
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Casein Kinase II Receptor Peptide is a substrate for casein kinase II with an Km value of 500 µM. Casein Kinase II Substrate can be used for measure casein kinase II activity in crude enzyme preparations .
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- HY-P1230
-
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Dipeptidyl Peptidase
GLP Receptor
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Metabolic Disease
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HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity .
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- HY-P2548
-
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EGFR
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Others
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pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is the phosphorylated peptide of an EGFR substrate. pp60 (v-SRC) Autophosphorylation Site, Phosphorylated can be used for the screening of EGFR Kinase inhibitors via phosphorylated-substrate quantification .
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- HY-P0228
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PKA
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Neurological Disease
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PKA RII peptide is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity .
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-
- HY-P3474
-
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MMP
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Cancer
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Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2 is a fluorescent peptide MMP substrate .
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-
- HY-P3918
-
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p38 MAPK
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Others
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EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity .
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- HY-P0228A
-
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PKA
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Metabolic Disease
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PKA RII peptide TFA is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity .
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- HY-P2377
-
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Fluorescent Dye
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Others
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Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .
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- HY-P5383
-
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MMP
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Others
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Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a biological active peptide. (MMP substrate)
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- HY-P3474A
-
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MMP
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Cancer
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Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2 (TFA) is a fluorescent peptide MMP substrate .
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- HY-P4773
-
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HSV
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Infection
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HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (kcat/Km) at pH 7.5 for cleavage is 5.2 M -1 s -1 .
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- HY-P0225
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Autocamtide II
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CaMK
Autophagy
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Neurological Disease
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Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay.
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- HY-123053
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Z-LLE-AMC
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Proteasome
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Others
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Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome
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- HY-135172
-
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Fluorescent Dye
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Others
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Suc-Leu-Tyr-AMC is a fluorometric peptide substrate for µ-calpain and m-calpain. The excitation wavelength is 360 nm and the emission wavelength is 460 nm .
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- HY-P5371
-
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Thrombin
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Others
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TFLLRNPNDK-NH2 is a biological active peptide. (This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.)
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- HY-P1906
-
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CDK
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Neurological Disease
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[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM .
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- HY-P1906A
-
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CDK
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Neurological Disease
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[pThr3]-CDK5 Substrate TFA is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM .
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-
- HY-10340
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KX2-391; KX-01
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Src
Microtubule/Tubulin
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Cancer
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Tirbanibulin (KX2-391) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
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- HY-10340A
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KX2-391 dihydrochloride; KX-01 dihydrochloride
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Src
Microtubule/Tubulin
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Cancer
|
Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
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- HY-10340B
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KX2-391 Mesylate; KX01 Mesylate
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Src
Microtubule/Tubulin
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Cancer
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Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
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-
- HY-131498
-
|
Fluorescent Dye
|
Others
|
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues .
|
-
- HY-P3892
-
|
PKC
|
Inflammation/Immunology
|
Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of PKC inactive .
|
-
- HY-P0020
-
tos-GPR-ANBA-IPA
|
Biochemical Assay Reagents
|
Others
|
Tos-Gly-Pro-Arg-ANBA-IPA is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA can be used for luminescence measurement .
|
-
- HY-P4399
-
|
Bacterial
ClpP
|
Others
|
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .
|
-
- HY-P2716
-
|
MMP
|
Others
|
Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 is a biological active peptide. (MMP substrate)
|
-
- HY-P2008
-
IEGR-AMC
|
Factor Xa
|
Cardiovascular Disease
|
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
|
-
- HY-112080
-
|
Histone Methyltransferase
|
Cancer
|
BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM .
|
-
- HY-120659
-
|
Fluorescent Dye
|
Others
|
Gly-Gly-AMC is a fluorogenic peptide substrate. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus .
|
-
- HY-137286
-
Z-Leu-Leu-Glu-β-naphthylamide
|
Proteasome
|
Others
|
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .
|
-
- HY-P3811
-
|
CaMK
|
Neurological Disease
|
Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca 2+/calmodulin-dependent kinase II) (CaMK) substrate .
|
-
- HY-P3811A
-
|
CaMK
|
Neurological Disease
|
Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca 2+/calmodulin-dependent kinase II) (CaMK) substrate .
|
-
- HY-D1705
-
|
Proteasome
|
Inflammation/Immunology
|
Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
|
-
- HY-19593
-
|
|
|
Nikkomycin Z, a nucleoside-peptide, is a selective competitive chitin synthesis inhibitor. Nikkomycin Z has antifungal effects and acts as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine .
|
-
- HY-P0020A
-
tos-GPR-ANBA-IPA acetate
|
|
|
Tos-Gly-Pro-Arg-ANBA-IPA (tos-GPR-ANBA-IPA) acetate is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA acetate can be used for luminescence measurement .
|
-
- HY-W027544
-
|
Fluorescent Dye
|
Others
|
MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
|
-
- HY-P4038
-
|
HCV Protease
|
Infection
|
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .
|
-
- HY-P0271
-
|
CaMK
Autophagy
|
Neurological Disease
|
Syntide 2, a Ca 2+- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .
|
-
- HY-150242A
-
|
Others
|
Others
|
Cbz-Ala-Ala-Asn TFA is a peptide that designed based on the sequence of the substrate of legumain. Legumain is a cysteine protease. Cbz-Ala-Ala-Asn TFA can be applied as a scaffold for drug delivery .
|
-
- HY-114365
-
UDP-N-acetyl-D-galactosamine disodium
|
Endogenous Metabolite
|
Metabolic Disease
|
UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor .
|
-
- HY-P0271A
-
|
CaMK
|
Neurological Disease
|
Syntide 2 (TFA), a Ca 2+- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .
|
-
- HY-B1190A
-
BL-S 578 hydrate
|
|
|
Cefadroxil hydrate (BL-S 578 hydrate) is an orally active and first-generation cephalosporin with a broad spectrum antibacterial activity. Cefadroxil hydrate (BL-S 578 hydrate) also acts as a substrate of the peptide transporter PEPT1 and PEPT2 .
|
-
- HY-133125
-
|
Others
|
Inflammation/Immunology
|
ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates .
|
-
- HY-P10173
-
|
Angiotensin-converting Enzyme (ACE)
|
Others
|
Abz-LFK(Dnp)-OH is an angiotensin I-converting enzyme (ACE) peptide substrate. Abz-LFK(Dnp)-OH is selective for the C domain of ACE. Abz-LFK(Dnp)-OH can be used to assess ACE activity .
|
-
- HY-111173
-
|
Dipeptidyl Peptidase
|
Others
|
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .
|
-
- HY-P3934
-
|
HIV Protease
|
Infection
|
HIV Protease Substrate I is a chromogenic substrate of HIV-1 protease. HIV Protease Substrate I has the cleavage site of HIV protease .
|
-
- HY-P4987
-
|
Protease Activated Receptor (PAR)
|
Cardiovascular Disease
|
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research .
|
-
- HY-P3437
-
|
Virus Protease
|
Others
|
Dabcyl-KTSAVLQSGFRKM-Glu(Edans)-NH2 is a fluorogenic peptide, as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKM-Glu(Edans)-NH2 can be used for researching 2019-nCoV (COVID-19) infection.
|
-
- HY-137870
-
gamma-Glutamyl-beta-naphthylamide
|
Biochemical Assay Reagents
|
|
γ-Glutamyl-β-naphthylamide is a substrate for γ-glutamine peptidase. γ-Glutamyl-β-naphthylamide is specifically recognized and the peptide chain is cleaved. γ-Glutamyl-β-naphthylamide can be used to distinguish between gonococci and meningococci .
|
-
- HY-W015450
-
|
Endogenous Metabolite
|
Others
|
D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase. D-Ala-D-Ala is a bacterial endogenous metabolite .
|
-
- HY-P5525
-
Autocamtide-3 Derived Inhibitory peptide
|
CaMK
|
Others
|
AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)
|
-
- HY-120833
-
|
Caspase
|
Others
|
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
|
-
- HY-P10172
-
-
- HY-118570
-
|
Others
|
Neurological Disease
|
5-Oxoprolyltryptophan is a model substrate for investigating the increase of serotonin at the cerebral level .
|
-
- HY-114645
-
|
PDK-1
|
Cancer
|
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1 .
|
-
- HY-P5272
-
|
Bacterial
|
Inflammation/Immunology
|
Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
|
-
- HY-134393
-
N6-Methyl-ATP
|
GSK-3
|
Others
|
6-Me-ATP (N6-Methyl-ATP) is a N 6-modified ATP derivative. 6-Me-ATP shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
|
-
- HY-P2089
-
|
MMP
|
Others
|
Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .
|
-
- HY-110196
-
|
Others
|
Others
|
(S)-PFI-2 hydrochloride is an inhibitor of lysine methyltransferase SETD7 and is approximately 500-fold more active than its enantiomer (R)-PFI-2. (R)-PFI-2 is a cofactor-dependent and substrate-competitive inhibitor. (R)-PFI-2 can occupy the substrate peptide binding groove of SETD7 (including the catalytic lysine binding channel) and interact with the cofactor The donor methyl group is in direct contact. However, (S)-PFI-2 was not observed to have the same interaction as (R)-PFI-2 .
|
-
- HY-P2536
-
-
- HY-P1986
-
|
Caspase
|
Cancer
|
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
|
-
- HY-134393B
-
N6-Methyl-ATP trisodium
|
GSK-3
|
Others
|
6-Me-ATP (N6-Methyl-ATP) trisodium is a N 6-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
|
-
- HY-18962
-
|
Histone Methyltransferase
|
Cancer
|
AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding .
|
-
- HY-126437A
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide. .
|
-
- HY-135773
-
|
Prostaglandin Receptor
PDK-1
|
Cardiovascular Disease
Inflammation/Immunology
|
CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist . CRTh2 antagonist 3 enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. CRTh2 antagonist 3 has the potential for cardiovascular inflammation .
|
-
- HY-P2810
-
EC 3.4.23.4
|
Endogenous Metabolite
Ser/Thr Protease
|
Metabolic Disease
|
Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues 105 and 106, phenylalanine and methionine, and is widely used in cheese production .
|
-
- HY-P4899
-
|
Beta-secretase
|
Neurological Disease
|
RE (EDANS) EVNLDAEFK (DABCYL) R is an EDANS and DABCYL double-labeled peptide,serves as a fluorescent substrate for BACE1(Em=360nm,Ex=528nm). RE (EDANS) EVNLDAEFK (DABCYL) R can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction .
|
-
- HY-18962A
-
|
Histone Methyltransferase
|
Cancer
|
AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding .
|
-
- HY-P1173
-
Myristoylated L 803; GSK-3β Inhibitor XIII
|
GSK-3
Amyloid-β
|
Neurological Disease
|
L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .
|
-
- HY-W062835
-
|
Src
|
Cancer
|
CGP77675 is an orally active and potent inhibitor of Src family kinases. CGP77675 inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50s of 5-20 and 40 nM, respectively), and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC50s of 5-20, 40, 20, 150, 1000, 310, and 290 nM, respectively. Anticancer activity .
|
-
- HY-136887
-
|
Others
|
Others
|
Arphamenine B (hemisulfate) is a Zn 2+-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B (hemisulfate) Arphamenine B (hemisulfate) is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B (hemisulfate) enhances the immune response and is used to characterize novel proteases .
|
-
- HY-W062835A
-
|
Src
|
Cancer
|
CGP77675 hydrate is an orally active and potent inhibitor of Src family kinases. CGP77675 hydrate inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50s of 5-20 and 40 nM, respectively),and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC50s of 0.02, 0.15, 1.0, 0.31, and 0.29 μM, respectively. Anticancer activity .
|
-
- HY-W027544S
-
7-Methoxy-d3-2-oxo-2H-1-benzopyran-4-acetic acid; 7-Methoxy-d3-2H-chromen-2-one-4-acetic acid
|
Isotope-Labeled Compounds
|
Others
|
(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].
|
-
- HY-P2185
-
|
MMP
|
Others
|
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
|
-
- HY-P2185A
-
|
MMP
|
Others
|
NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
|
-
- HY-101117
-
EED226
Maximum Cited Publications
7 Publications Verification
|
Histone Methyltransferase
|
Cancer
|
EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model . EED226 is a potent, selective, and orally bioavailable EED inhibitor . EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays .
|
-
- HY-P4919
-
|
Beta-secretase
|
Others
|
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
|
-
- HY-P6023
-
|
Factor Xa
|
Cardiovascular Disease
|
D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity .
|
-
- HY-P6023B
-
|
Factor Xa
|
Cardiovascular Disease
|
D-Leu-Pro-Arg-Rh110-D-Pro acetate is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro acetate consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro acetate can be used to detect FXIa activity .
|
-
- HY-P6023A
-
|
Factor Xa
|
Cardiovascular Disease
|
D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro TFA consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro TFA can be used to detect FXIa activity .
|
-
- HY-P5380
-
|
MMP
|
Others
|
TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)
|
-
- HY-155995
-
MK-905
|
Others
|
Cancer
|
Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) .
|
-
- HY-W027544S1
-
5-(Dimethyl-d6-amino)-N-(prop-2-ynyl)naphthalene-1-sulfonamide
|
Isotope-Labeled Compounds
|
Others
|
(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
Cat. No. |
Product Name |
Type |
-
- HY-P1448
-
-
- HY-P2377
-
|
Dyes
|
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .
|
-
- HY-P3791
-
|
Fluorescent Dyes/Probes
|
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
|
-
- HY-W324458
-
|
Fluorescent Dyes/Probes
|
MCA succinimidyl ester is a derivative of MCA (HY-W027544). MCA succinimidyl ester has succinimidyl ester can react selectively with amines. MCA succinimidyl ester can be used as peptide substrate for fluorescence resonance energy transfer .
|
-
- HY-P3474
-
-
- HY-131498
-
|
Fluorescent Dyes/Probes
|
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues .
|
-
- HY-D1705
-
|
Fluorescent Dyes/Probes
|
Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
|
-
- HY-W027544
-
|
Fluorescent Dyes/Probes
|
MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
|
-
- HY-P2536
-
|
Fluorescent Dyes/Probes
|
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .
|
-
- HY-P1986
-
|
Fluorescent Dyes/Probes
|
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
|
-
- HY-P2185
-
|
Dyes
|
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
|
Cat. No. |
Product Name |
Type |
-
- HY-114365
-
UDP-N-acetyl-D-galactosamine disodium
|
Biochemical Assay Reagents
|
UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor .
|
-
- HY-134393B
-
N6-Methyl-ATP trisodium
|
Gene Sequencing and Synthesis
|
6-Me-ATP (N6-Methyl-ATP) trisodium is a N 6-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
|
-
- HY-126437A
-
|
Drug Delivery
|
Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide. .
|
-
- HY-P2810
-
EC 3.4.23.4
|
Biochemical Assay Reagents
|
Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues 105 and 106, phenylalanine and methionine, and is widely used in cheese production .
|
-
- HY-137870
-
gamma-Glutamyl-beta-naphthylamide
|
Cell Assay Reagents
|
γ-Glutamyl-β-naphthylamide is a substrate for γ-glutamine peptidase. γ-Glutamyl-β-naphthylamide is specifically recognized and the peptide chain is cleaved. γ-Glutamyl-β-naphthylamide can be used to distinguish between gonococci and meningococci .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1344A
-
|
DAPK
|
Cancer
|
DAPK Substrate Peptide TFA is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM .
|
-
- HY-P3815
-
|
Casein Kinase
|
Others
|
Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide. Casein Kinase 2 Substrate Peptide is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). Casein Kinase 2 Substrate Peptide can be used for protein kinase CK2 activity determination .
|
-
- HY-P1344
-
|
Peptides
|
Cancer
|
DAPK Substrate Peptide is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM .
|
-
- HY-P3814
-
|
Ribosomal S6 Kinase (RSK)
|
Cancer
|
S6 Kinase Substrate Peptide 32 is a substrate of Ribosomal S6 Kinase (RSK). S6 Kinase Substrate Peptide 32 can be used to measure the activity of RSKs which phosphorylate ribosomal protein S6 .
|
-
- HY-P2505
-
|
Syk
|
Others
|
Syk Kinase Peptide Substrate is a Syk kinase peptide substrate.
|
-
- HY-P2513
-
|
Peptides
|
Others
|
Src Optimal Peptide Substrate is a highly specific Src substrate. Src Optimal Peptide Substrate can used to measure the Src activity .
|
-
- HY-P1797A
-
|
Peptides
|
Others
|
Sakamototide substrate peptide TFA is a peptide substrate for members of the AMPK family of kinases, used in kinase activity assays .
|
-
- HY-P0141
-
|
Akt
|
Others
|
Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or
MAPK1 .
|
-
- HY-P2504
-
|
Syk
|
Others
|
Syk Kinase Peptide Substrate, Biotin labeled is a biotin-labled Syk kinase peptide substrate.
|
-
- HY-P0141A
-
|
Akt
|
Others
|
Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .
|
-
- HY-P3818
-
|
PKC
|
Others
|
PKCδ Peptide Substrate is an absolutely specific substrate for the δ-type of PKC, with a sequence corresponding to sequence 422-443 of murine eEF-1α and containing Thr-431 .
|
-
- HY-P5526
-
|
Peptides
|
Others
|
CCK1-specific peptide substrate is a biological active peptide. (This peptide sequence is based on rabbit muscle glycogen synthase with Ser7 phosphorylated. It is a peptide substrate for Casein Kinase I (CK1). CK1 phosphorylates Ser10. Ser7 is phosphorylated by PKA in vivo.)
|
-
- HY-P1113
-
|
GSK-3
|
Others
|
Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .
|
-
- HY-P1113A
-
|
GSK-3
|
Others
|
Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .
|
-
- HY-P5434
-
JAK3 peptide substrate
|
Peptides
|
Others
|
Jak3tide (JAK3 Peptide substrate) is a biological active peptide. (This peptide is a substrate for Jak3. It may be used used in kinase assays. Jak3tide contains the phosphorylation site at Tyr7.)
|
-
- HY-P5432
-
IRAK-1 (360-380)
|
Peptides
|
Others
|
IRAK-4 Peptide substrate (IRAK-1 (360-380)) is a biological active peptide. (This is a substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4)
|
-
- HY-P3904
-
|
Biochemical Assay Reagents
|
Others
|
P34cdc2 Kinase Substrate Peptide is a synthetic peptide substrates for P34 cdc2 kinase, with a Km of 74 μM for the purified human enzyme. P34cdc2 Kinase Substrate Peptide can be used in a rapid assay of P34 cdc2 phosphorylation in vitro. P34 cdc2, a protein serinehhreonine kinase, is a cell division cycle-regulated protein kinase .
|
-
- HY-P1803
-
PKCε; PRKCE ; peptide Epsilon
|
Peptides
|
Neurological Disease
Inflammation/Immunology
Endocrinology
|
Protein Kinase C Peptide Substrate is targeted to a specific cellular compartment in a manner dependent on second messengers and on specific adapter proteins in response to extracellular signals that activate G-protein-coupled receptors, tyrosine kinase receptors, or tyrosine kinase-coupled receptors. Protein Kinase C Peptide Substrate then regulates various physiological functions including the activation of nervous, endocrine, exocrine, inflammatory, and immune systems .
|
-
- HY-P10143
-
|
Peptides
|
Others
|
MMP-2/MMP-9 Substrate, a synthetic colorimetric substrate, is a peptide .
|
-
- HY-P4520
-
|
Peptides
|
Others
|
(Trp4)-Kemptide is a peptide substrate for adenosine 3',5'-cyclic monophosphate-dependent protein kinase .
|
-
- HY-P3921
-
|
Casein Kinase
|
Cancer
|
Casein Kinase II Substrate is a casein kinase II (CK2) peptide substrate that can be selectively phosphorylated by CK2 .
|
-
- HY-P10163
-
|
Fluorescent Dye
|
Others
|
α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm
|
-
- HY-P3920
-
|
PKA
|
Cancer
|
Cys-Kemptide is a cysteine-terminated substrate peptide that can used to measure protein kinase A (PKA) activity .
|
-
- HY-P2162
-
|
Myosin
|
Cancer
|
Kemptamide, a 13 amino acid fragment with a sequence corresponding to residues 11-23 of gizzard light chain. Kemptamide is a peptide substrate of myosin light-chain kinase (MLCK) .
|
-
- HY-P4334
-
Bz-Arg-Gly-Phe-Phe-Leu-4MβNA
|
Peptides
|
Others
|
Bz-RGFFL-4MβNA (Bz-Arg-Gly-Phe-Phe-Leu-4MβNA) is a peptide and can be used fluorogenic substrate .
|
-
- HY-P10082
-
|
Caspase
|
Others
|
Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
|
-
- HY-P3722
-
|
Fluorescent Dye
MMP
|
Others
|
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
|
-
- HY-P3722A
-
|
Fluorescent Dye
MMP
|
Others
|
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE); ADAM17, ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
|
-
- HY-P1486
-
|
Endogenous Metabolite
|
Cardiovascular Disease
|
Angiotensinogen (1-14), human is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .
|
-
- HY-P1486A
-
|
Endogenous Metabolite
|
Cardiovascular Disease
|
Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .
|
-
- HY-P3940
-
|
PKC
|
Others
|
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .
|
-
- HY-P3743
-
|
Peptides
|
Others
|
p60c-src Substrate is an efficient and specific substrate for p60c-src protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .
|
-
- HY-P3791
-
|
Fluorescent Dye
|
Others
|
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
|
-
- HY-P5970
-
TACE substrate
|
Peptides
|
Cancer
|
DABCYL-TNF-α-EDANS (-4 to +6) (human) is a FRET peptide substrate of tumor necrosis factor convertase (TACE) .
|
-
- HY-P2509
-
|
Peptides
|
Others
|
Histone H2A (1-20), a 35-residue a peptide of histone H2A, is a substrate for methyltransferase/demethylase enzymes .
|
-
- HY-P5915
-
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2, a 5-FAM labeled HIF-1α peptide, is a substrate of VHL. FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 binds to VHL protein with a KD of 3 nM. Ex/Em (λ) = 485/520 nm .
|
-
- HY-P1115A
-
|
Akt
|
Others
|
AKTide-2T TFA is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T TFA mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position .
|
-
- HY-P2295
-
|
SARS-CoV
|
Others
|
Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .
|
-
- HY-P4931
-
Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
|
MMP
|
Cancer
|
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
|
-
- HY-P1821
-
MHP4-14
|
PKC
|
Neurological Disease
|
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca 2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .
|
-
- HY-P1583
-
-
- HY-P3944
-
|
CaMK
|
Neurological Disease
|
Calmodulin Dependent Protein Kinase Substrate is a Ca 2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide substrate for protein kinases .
|
-
- HY-P3943
-
|
CaMK
|
Neurological Disease
|
Calmodulin Dependent Protein Kinase Substrate Analog is a Ca 2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide substrate for protein kinases .
|
-
- HY-P5449
-
|
Peptides
|
Others
|
p70 S6 Kinase substrate is a biological active peptide. (This peptide is a substrate for p70 ribosomal S6 kinase.)
|
-
- HY-P10064
-
|
Peptides
|
Others
|
Akt Substrate (Akt/SKG substrate) is a 7 amino acid synthetic peptide suitable as a substrate for Akt .
|
-
- HY-P4530
-
|
Peptides
|
Others
|
D-Ala-Gly-Gly-OH is a peptide substrate. DppA has a poor efficiency on peptide substrates D-Ala-Gly-Gly-OH .
|
-
- HY-P10100
-
-
- HY-P5428
-
|
Peptides
|
Others
|
Cdc2 kinase substrate is a biological active peptide. (The native peptide HATPPKKKRK is a substrate for cyclin-dependent protein kinase 1 (CDC2; CDK1).)
|
-
- HY-P3797
-
|
Furin
|
Cancer
|
Furin Substrate is an peptide. Furin Substrate can be used for the research of various biochemical .
|
-
- HY-P2668
-
|
Peptides
|
Others
|
Cdk5 Substrate is a biological active peptide. (substrate for the cdc2 protein kinase)
|
- HY-P5385
-
|
Peptides
|
Others
|
Renin substrate, angiotensinogen (1-14), rat is a biological active peptide. (This peptide is derived from rat angiotensinogen amino acid residues 1-14. It is a synthetic renin substrate.)
|
- HY-P5965
-
|
Peptides
|
Others
|
BiP substrate is a peptide substrate of BiP that can be used to measure the BiP ATPase activity .
|
- HY-P5375
-
|
Peptides
|
Others
|
O-Linked GlcNAc transferase substrate is a biological active peptide. (A peptide substrate of O-linked GlcNAc transferase (OGT), a eukaryotic glycosyltransferase that uses UDP-GlcNAc as a glycosyl donor.)
|
- HY-P5507
-
Erktide
|
Peptides
|
Others
|
ERK2 Substrate (Erktide) is a biological active peptide. (Erktide is a peptide substrate for ERK2 (extracellular regulated protein kinase 2) whose activity is regulated by mitogenic stimuli.)
|
- HY-P10098
-
|
PKA
|
Cancer
|
PKA Substrate is a potent and selective substrate peptide of PKA that can be used to detect PKA activity .
|
- HY-P1576
-
- HY-P2547
-
|
Src
|
Others
|
Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay .
|
- HY-P5456
-
|
Peptides
|
Others
|
KRPpSQRHGSKY-NH2 is a biological active peptide. (This is a phosphorylated PKC substrate peptide)
|
- HY-P5433F
-
|
Peptides
|
Others
|
IRS-1 Peptide, FAM labeled is a biological active peptide. (Insulin receptor substrate)
|
- HY-P5450
-
|
PDK-1
|
Others
|
PDKtide is a biological active peptide. (This peptide is a substrate for PDK1 (Phosphatidylinositide-Dependent Kinase 1).)
|
- HY-P10008
-
|
Cathepsin
|
Cancer
|
Cathepsin D/E Substrate, Fluorogenic, 11 amino acid peptide, is a selective substrate for cathepsins D and E. Cathepsin D/E Substrate, Fluorogenic does not act as a substrate for cathepsins B, H, or L .
|
- HY-P5441
-
|
Peptides
|
Others
|
KRpTIRR is a biological active peptide. (Phosphatase substrate.)
|
- HY-P5447
-
|
Peptides
|
Others
|
RRLIEDAEpYAARG is a biological active peptide. (Phosphatase substrate.)
|
- HY-P10036
-
|
PKG
|
Others
|
G-Subtide is a G-substrate peptide localized in Purkinje cells of the cerebellum. G-Subtide has little activity distinct from background and is a preferentially phosphorylated peptide substrate of recombinant PfPKG2 protein .
|
- HY-P5473
-
|
Peptides
|
Others
|
EA2 is a biological active peptide. (This is a peptide substrate for polypeptide N-acetylgalactosaminyltransferase (polypeptide GalNAc-T).)
|
- HY-P1448
-
- HY-P3123
-
|
Peptides
|
Others
|
Dnp-RPLALWRS is a biological active peptide. (matrilysin substrate)
|
- HY-P0248F
-
|
Peptides
|
Others
|
Kemptide, 5-FAM labeled is a biological active peptide. (Kemptide is a phosphate acceptor peptide that serves as a synthetic substrate for PKA (Km = 16 μM). The corresponding fluorescent and biotinylated peptides are also proven to be good substrates for PKA. 5-FAM labeled HY-P0248)
|
- HY-P5433
-
|
Peptides
|
Others
|
IRS1-derived peptide is a biological active peptide. (This is a peptide fragment (979-989) of the insulin receptor substrate-1 containing the sequence motif YMXM known to bind to the two domains of SH2 on the 85kDa subunit of phosphoinositide 3-kinase.)
|
- HY-P2492
-
|
Peptides
|
Metabolic Disease
|
Renin FRET Substrate I is a substrate of human renin. Renin FRET Substrate I is designed to incorporate the renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen .
|
- HY-P5485
-
|
Peptides
|
Others
|
Dabcyl-QALPETGEE-Edans is a biological active peptide. (Sortase Substrate)
|
- HY-P4342
-
- HY-P4345
-
- HY-P3770
-
|
PKC
|
Others
|
Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak PKC inhibitor .
|
- HY-P5998
-
|
Myosin
|
Cancer
|
Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate .
|
- HY-P5454
-
|
Peptides
|
Others
|
RS Domain derived peptide is a biological active peptide. (This peptide is a substrate for Clk/Sty and is phosphorylated by Clk/Sty protein kinase (Km=102 microM).)
|
- HY-P5431
-
|
Peptides
|
Others
|
Insulin receptor (1142-1153), pTyr1150 is a biological active peptide. (Peptide used as insulin receptor tyrosine kinase substrate.)
|
- HY-P5426
-
|
Peptides
|
Others
|
Abl protein tyrosine kinase substrate is a biological active peptide. (Abltide is a peptide substrate for Abl Kinase (Abl protein tyrosine kinase), a partner in the gag-Abl fusion protein of the Abelson murine leukemia virus. Used in Western blot and kinase assay.)
|
- HY-P5939
-
|
Angiotensin Receptor
|
Cardiovascular Disease
|
Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .
|
- HY-P0136
-
SAMS
2 Publications Verification
|
AMPK
|
Metabolic Disease
|
SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
|
- HY-P5445
-
|
Peptides
|
Others
|
Neurogranin 28-43 is a biological active peptide. (selective PKC substrate)
|
- HY-P4341
-
- HY-P4348
-
|
Proteasome
|
Others
|
MeOSuc-Gly-Leu-Phe-AMC is a peptide substrate of proteasomal .
|
- HY-P4361
-
- HY-P4363
-
|
Peptides
|
Others
|
Suc-GPLGP-AMC is a peptide substrate of collagenase-like peptidases .
|
- HY-P6028
-
|
Peptides
|
Others
|
GSNKSKPK-NH2 is a model peptide based on a c-Src N-terminal peptide that can be used as NMT substrate .
|
- HY-P5376
-
|
Peptides
|
Others
|
MeOSuc-Arg-Pro-Tyr-pNA is a biological active peptide. (chymotrypsin substrate)
|
- HY-P4343
-
|
Peptides
|
Others
|
Lys(Abz)-Pro-Pro-pNA is a fluorescent peptide substrate of PepP .
|
- HY-P4344
-
|
MetAP
|
Others
|
Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .
|
- HY-P4366
-
- HY-P4390
-
- HY-P4347
-
|
Peptides
|
Others
|
MeOSuc-Ala-Phe-Lys-AMC TFA is a peptide substrate of plasmin .
|
- HY-P2480
-
|
Peptides
|
Others
|
Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDKs .
|
- HY-P6028A
-
|
Peptides
|
Others
|
GSNKSKPK-NH2 TFA is a model peptide based on a c-Src N-terminal peptide that can be used as NMT substrate .
|
- HY-P1746
-
PKC (19-31)
|
PKC
|
Inflammation/Immunology
|
Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .
|
- HY-P0320
-
|
Phosphatase
|
Others
|
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
|
- HY-P0320A
-
|
Phosphatase
Biochemical Assay Reagents
|
Others
|
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
|
- HY-P0320B
-
|
Phosphatase
Biochemical Assay Reagents
|
Others
|
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
|
- HY-P5429
-
|
Peptides
|
Others
|
DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
|
- HY-P2714
-
- HY-P1746A
-
PKC (19-31) (TFA)
|
PKC
|
Inflammation/Immunology
|
Protein Kinase C (19-31) TFA, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .
|
- HY-P1595
-
|
PKA
|
Metabolic Disease
|
CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.
|
- HY-P5386
-
|
Peptides
|
Others
|
H-d-Val-Leu-Arg-AFC is a biological active peptide. (kallikrein substrate)
|
- HY-P4338
-
|
PAI-1
|
Others
|
Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .
|
- HY-P4350
-
|
Elastase
|
Others
|
Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like .
|
- HY-P4471
-
- HY-P2559
-
|
CDK
|
Cancer
|
CDK7/9 tide is peptide substrate for CDK7 or CDK9 .
|
- HY-P2558
-
|
GSK-3
|
Others
|
GSK3 Substrate, α, β subunit is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used to measure GSK-3 activity .
|
- HY-P2171
-
|
Peptides
|
Inflammation/Immunology
|
CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .
|
- HY-P5348
-
|
Peptides
|
Others
|
Ac-LEHD-pNA is a biological active peptide. (Caspase-9 substrate; pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. pNA has maximum absorption around 408 nm.)
|
- HY-P4381
-
- HY-P4514
-
|
Peptides
|
Others
|
Z-Gly-Gly-Arg-βNA is the synthetic peptide substrate of trypsin-like activities of the proteasome .
|
- HY-P4364
-
|
Peptides
|
Others
|
Suc-Phe-Leu-Phe-4MβNA is a fluorescent peptide substrate .
|
- HY-P4359
-
|
PIN1
|
Others
|
Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .
|
- HY-P10060
-
- HY-P2171A
-
|
Peptides
|
Inflammation/Immunology
|
CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .
|
- HY-P5353
-
IKVAV sequence; Laminin A-chain fragment
|
Peptides
|
Others
|
PA22-2 (IKVAV sequence; Laminin A-chain fragment) is a biological active peptide. (This peptide is derived from mouse laminin a1 . Cell matrix substrate constituted with this peptide can promote neurite outgrowth.)
|
- HY-P1576A
-
- HY-P4490
-
- HY-P4346
-
|
Elastase
|
Others
|
MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases .
|
- HY-P4388
-
|
SARS-CoV
|
Infection
|
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL pro .
|
- HY-P1883
-
|
Fluorescent Dye
|
Infection
|
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
|
- HY-P4209
-
|
Peptides
|
Others
|
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
- HY-P5378
-
Cathepsin S substrate
|
Peptides
|
Others
|
Ac-KQKLR-AMC (Cathepsin S substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin S is a cysteine proteinase involved in the pathogenesis of autoimmune diseases, atherosclerosis, cancer, obesity and related diseases.This peptide is a cathepsin S substrate fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). It can be used to measure cathepsin S activity.)
|
- HY-P5440
-
|
ERK
|
Others
|
ERKtide is a biological active peptide. (ERKtide is a peptide substrate for ERK2. Extracellular regulated protein kinase 2 (ERK2) is a eukaryotic protein kinase whose activity is regulated by mitogenic stimuli.)
|
- HY-P5466
-
|
Peptides
|
Others
|
S6(229-239) is a biological active peptide. (This is a synthetic peptide substrate for S6 kinase shown to be phosphorylated by protein kinase c with phosphorylation site identified at Ser235)
|
- HY-W436471
-
|
Peptides
|
Others
|
H-Ala-Pro-AFC is a biological active peptide. (This is a fluorescent peptide, Abs/Em=380/500nm. It is a substrate for dipeptidyl peptidase IV (DPP IV) and Xaa-Pro dipeptidase.)
|
- HY-P1595A
-
|
PKA
|
Metabolic Disease
|
CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a PKA substrate .
|
- HY-P4209A
-
|
Peptides
|
Others
|
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
- HY-P1883A
-
|
Fluorescent Dye
|
Infection
|
Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
|
- HY-P0315
-
|
Akt
|
Others
|
Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.
|
- HY-P0291
-
|
PKA
|
Others
|
Kemptide (Phospho-Ser5) is a phosphate acceptor peptide that serves as a specific substrate for cAMP-dependent protein kinase (PKA).
|
- HY-106377A
-
- HY-137834A
-
|
Peptides
|
Others
|
Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)
|
- HY-P5467
-
|
Peptides
|
Others
|
S6(229-239), Amide, biotinalyted is a biological active peptide. (substrate for Rho-Kinase II)
|
- HY-P3748
-
|
Casein Kinase
|
Others
|
Casein Kinase II Receptor Peptide is a substrate for casein kinase II with an Km value of 500 µM. Casein Kinase II Substrate can be used for measure casein kinase II activity in crude enzyme preparations .
|
- HY-P1230
-
|
Dipeptidyl Peptidase
GLP Receptor
|
Metabolic Disease
|
HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity .
|
- HY-P1820
-
|
Peptides
|
Infection
|
SNAP-25 (187-203), a peptide corresponding to residues 187–203 of SNAP-25, is a substrate for botulinum neurotoxin (BoNT)/A and can be used as a substrate for quantifying the activity of BoNT/C1(1-430) .
|
- HY-P2548
-
|
EGFR
|
Others
|
pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is the phosphorylated peptide of an EGFR substrate. pp60 (v-SRC) Autophosphorylation Site, Phosphorylated can be used for the screening of EGFR Kinase inhibitors via phosphorylated-substrate quantification .
|
- HY-P0228
-
|
PKA
|
Neurological Disease
|
PKA RII peptide is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity .
|
- HY-P3474
-
|
MMP
|
Cancer
|
Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2 is a fluorescent peptide MMP substrate .
|
- HY-P3918
-
|
p38 MAPK
|
Others
|
EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity .
|
- HY-P4425
-
|
Peptides
|
Others
|
Gly-Phe-AFC is a fluorescent substrate, which is a peptide sequence composed of glycine and phenylalanine, linked to the fluorescent group AFC .
|
- HY-P5374
-
|
Peptides
|
Others
|
MeOSuc-AAPV-AFC is a biological active peptide. (A highly specific neutrophil elastase substrate, Abs/Em=380/500 nm.)
|
- HY-P4891
-
|
Peptides
|
Others
|
Angiotensin (1-12) (human) is an endogenous substrate for the production of biologically active angiotensin peptides by a non-renin-dependent mechanism .
|
- HY-P0228A
-
|
PKA
|
Metabolic Disease
|
PKA RII peptide TFA is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity .
|
- HY-P2377
-
|
Fluorescent Dye
|
Others
|
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .
|
- HY-P5383
-
|
MMP
|
Others
|
Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a biological active peptide. (MMP substrate)
|
- HY-P5512
-
|
Peptides
|
Others
|
MUC5AC-3 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)
|
- HY-P3474A
-
|
MMP
|
Cancer
|
Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2 (TFA) is a fluorescent peptide MMP substrate .
|
- HY-P3115
-
|
Peptides
|
Others
|
Ac-LEVD-AFC is capspase-4 fluorogenic substrate peptide that can be used for caspase-4 activity studies .
|
- HY-P4773
-
|
HSV
|
Infection
|
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (kcat/Km) at pH 7.5 for cleavage is 5.2 M -1 s -1 .
|
- HY-P3794
-
|
Peptides
|
Infection
|
Glu-Ala-Leu-Phe-Gln-pNA is a Chiba virus 3C-like protease (CVP) substrate .
|
- HY-P5510
-
HCV NS3 protease substrate
|
Peptides
|
Others
|
Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) is a biological active peptide. (This peptide is a HCV protease substrate incorporating an ester bond between residues P1 and P1. Due to ready transesterification of the scissile bond to the acyl-enzyme intermediate, this substrate shows very high kcat/Km values, enabling detection of activity with subnanomolar nonstructural protein 3 (NS3 protease) concentrations. It is widely used for the continuous assay of NS3 protease activity. Substrate cleavage is proportional to the enzyme concentration with a detection limit for NS3 between 1 nM and 250 pM. Upon cleavage of this substrate, fluorescence can be monitored at Abs/Em = 355/500 nm.)
|
- HY-P0225
-
Autocamtide II
|
CaMK
Autophagy
|
Neurological Disease
|
Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay.
|
- HY-P5355
-
|
Peptides
|
Others
|
Z-Gly-Gly-Arg-AFC is a biological active peptide. (Plasminogen Activator Acrosine Substrate, fluorescent Z-Gly-Gly-Arg-AFC)
|
- HY-P5511
-
|
Peptides
|
Others
|
MUC5AC-3/13 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)
|
- HY-123053
-
Z-LLE-AMC
|
Proteasome
|
Others
|
Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome
|
- HY-135172
-
|
Fluorescent Dye
|
Others
|
Suc-Leu-Tyr-AMC is a fluorometric peptide substrate for µ-calpain and m-calpain. The excitation wavelength is 360 nm and the emission wavelength is 460 nm .
|
- HY-P1834
-
|
Peptides
|
Inflammation/Immunology
|
MARCKS Peptide(151-175), Phosphorylated is a phosphorylated peptide corresponding to the basic effector domain of myristoylated alanine-rich protein kinase C substrate protein (MARCKS). Phosphorylation of MARCKS Peptide (151-175) reverses its inhibition of phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) .
|
- HY-P5371
-
|
Thrombin
|
Others
|
TFLLRNPNDK-NH2 is a biological active peptide. (This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.)
|
- HY-P1906
-
|
CDK
|
Neurological Disease
|
[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM .
|
- HY-P1906A
-
|
CDK
|
Neurological Disease
|
[pThr3]-CDK5 Substrate TFA is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM .
|
- HY-P3892
-
|
PKC
|
Inflammation/Immunology
|
Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of PKC inactive .
|
- HY-P0020
-
tos-GPR-ANBA-IPA
|
Biochemical Assay Reagents
|
Others
|
Tos-Gly-Pro-Arg-ANBA-IPA is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA can be used for luminescence measurement .
|
- HY-P4399
-
|
Bacterial
ClpP
|
Others
|
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .
|
- HY-P2716
-
|
MMP
|
Others
|
Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 is a biological active peptide. (MMP substrate)
|
- HY-P5352
-
|
Peptides
|
Others
|
Hyaluronan-IN-1 is a biological active peptide. (This 12 amino acids peptide is a hyaluronan inhibitor (HA), a high molecular weight glycosaminoglycan expressed abundantly in the extracellular matrix and on cell surfaces. This peptide shows specific binding to soluble, immobilized, and cell-associated forms of HA, and it inhibits leukocyte adhesion to HA substrates almost completely.)
|
- HY-P2008
-
IEGR-AMC
|
Factor Xa
|
Cardiovascular Disease
|
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
|
- HY-P5326
-
|
Peptides
|
Others
|
EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH is a biological active peptide. (Plasmepsin I substrate)
|
- HY-137286
-
Z-Leu-Leu-Glu-β-naphthylamide
|
Proteasome
|
Others
|
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .
|
- HY-P0136F
-
|
Peptides
|
Others
|
FAM-SAMS is a biological active peptide. (5-FAM labeled HY-P0136. This FAM labeled peptide (Abs/Em = 494/521 nm) can be used as a substrate for 5-AMP-activated protein kinase (AMPK) in in vitro kinase assays.)
|
- HY-P3811
-
|
CaMK
|
Neurological Disease
|
Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca 2+/calmodulin-dependent kinase II) (CaMK) substrate .
|
- HY-P5430
-
|
Peptides
|
Others
|
DYRKtide is a biological active peptide. (Dyrktide is designed as the optimal substrate sequence efficiently phosphorylated by DYRK1A, which is a dual-specificity protein kinase that is thought to be involved in brain development.)
|
- HY-P5529
-
|
Peptides
|
Others
|
2Abz-GLQRALEI-Lys(Dnp)-NH2 is a biological active peptide. (C4 P4-P4′ substrate)
|
- HY-P3811A
-
|
CaMK
|
Neurological Disease
|
Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca 2+/calmodulin-dependent kinase II) (CaMK) substrate .
|
- HY-P5377
-
Cathepsin K substrate
|
Peptides
|
Others
|
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)
|
- HY-P5481
-
|
Peptides
|
Others
|
DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.)
|
- HY-P5323
-
|
Peptides
|
Others
|
Dabcyl-AGHDAHASET-Edans is a biological active peptide. (This is a type I signal peptidase (SPase1) substrate peptide labeled with EDANS/ DABCYL FRET pair, and contains a crucial cleavage site derived from the C-terminal region of the Staphylococcus epidermidis pre-SceD protein. Abs/Em = 340/490 nm.)
|
- HY-P10161
-
|
Peptides
|
Others
|
Ac-DMQD-pNA is a peptide substrate. Both of the recombinant CgCaspase-1 (rCgCaspase-1) and the C-terminus of CgCaspase-1 (rCgCaspase-1-C) exhibits similar caspase activity towards proteolytic substrate Ac-DMQD-pNA and Ac-DEVD-pNA (HY-P1006) .
|
- HY-P1183
-
|
Peptides
|
Neurological Disease
Endocrinology
|
Locustatachykinin I is a insect tachykinin-related peptide isolated from Locusta migratoria. Locustatachykinin I exhibits sequence homologies with the vertebrate tachykinins. In Lacanobia, Locustatachykinin I is also a substrate for a deamidase .
|
- HY-P5530
-
|
Peptides
|
Others
|
2Abz-SVARTLLV-Lys(Dnp)-NH2 is a biological active peptide. (C1-inhibitor P4-P4′ substrate)
|
- HY-P5415
-
|
Peptides
|
Others
|
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
|
- HY-P4038
-
|
HCV Protease
|
Infection
|
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .
|
- HY-P0271
-
|
CaMK
Autophagy
|
Neurological Disease
|
Syntide 2, a Ca 2+- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .
|
- HY-P5344
-
Fluorigenic PEXEL peptide
|
Peptides
|
Others
|
Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)
|
- HY-P0271A
-
|
CaMK
|
Neurological Disease
|
Syntide 2 (TFA), a Ca 2+- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .
|
- HY-P5435
-
|
Peptides
|
Others
|
LKBtide is a biological active peptide. (This is a peptide substrate that is phosphorylated by Serine/Threonine kinase 11 (STK11), also known as LKB1. LKBtide is derived from sucrose non-fermenting 1 (SNF1) protein kinase, which is normally activated by the LKB1/AMP-activated protein kinase (AMPK) signaling pathway.)
|
- HY-P1183A
-
|
Peptides
|
Neurological Disease
Endocrinology
|
Locustatachykinin I TFA is a insect tachykinin-related peptide isolated from Locusta migratoria. Locustatachykinin I TFA exhibits sequence homologies with the vertebrate tachykinins. In Lacanobia, Locustatachykinin I TFA is also a substrate for a deamidase .
|
- HY-P5356
-
Plasmin substrate
|
Peptides
|
Others
|
H-D-Val-Leu-Lys-AFC (Plasmin substrate) is a biological active peptide. (This is a fluorescent plasmin substrate, Abs/Em=380/500 nm.Plasmin belongs to the family of serine proteases. It plays a key role in fibrinolysis by dissolving fibrin in blood clots. Besides fibrinolysis, plasmin is also involved in such physiological and pathological processes as wound healing, liver repair, and the maintenance of liver homeostasis.)
|
- HY-P10173
-
|
Angiotensin-converting Enzyme (ACE)
|
Others
|
Abz-LFK(Dnp)-OH is an angiotensin I-converting enzyme (ACE) peptide substrate. Abz-LFK(Dnp)-OH is selective for the C domain of ACE. Abz-LFK(Dnp)-OH can be used to assess ACE activity .
|
- HY-111173
-
|
Dipeptidyl Peptidase
|
Others
|
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .
|
- HY-P3792
-
|
Peptides
|
Others
|
Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) is a FRET substrate of Thimet oligopeptidase. Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) can be used for the determination of Thimet oligopeptidase activity .
|
- HY-P3934
-
|
HIV Protease
|
Infection
|
HIV Protease Substrate I is a chromogenic substrate of HIV-1 protease. HIV Protease Substrate I has the cleavage site of HIV protease .
|
- HY-P2554
-
|
Peptides
|
Others
|
Histone H3 (1-25), amide is an N-terminal peptide fragment of histone H3. Histone H3 (1-25), amide can be used to identify the substrate for histone methyltransferases (HMTs). Histone H3 (1-25), amide, as a substrate for HMT G9a, shows more efficient than histone H3 (15-39) and full-length histone H3 .
|
- HY-P4987
-
|
Protease Activated Receptor (PAR)
|
Cardiovascular Disease
|
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research .
|
- HY-P5438
-
|
Peptides
|
Others
|
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)
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- HY-P5527F
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Peptides
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Others
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FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)
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- HY-P3437
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Virus Protease
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Others
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Dabcyl-KTSAVLQSGFRKM-Glu(Edans)-NH2 is a fluorogenic peptide, as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKM-Glu(Edans)-NH2 can be used for researching 2019-nCoV (COVID-19) infection.
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- HY-P5528
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Peptides
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Others
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2Abz-SLGRKIQIK(Dnp)-NH2 is a biological active peptide. (This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.)
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- HY-P5312
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Peptides
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Infection
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Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is a WNV NS2B-NS3 protease substrate. Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is used for WNV NS2B-NS3 protease substrate peptide selective inhibitor development .
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- HY-P5354
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Peptides
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Others
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FRETS-VWF73 is a biological active peptide. (FRETS-VWF73 is a very powerful Fluorescence-Quenching Substrate for the VWF cleaving protease ADAMTS-13. It is commonly used as a useful tool for the rapid measurement of ADAMTS-13 activity in plasma and is a predictive marker for various thrombotic diseases like TPP. Our new substrate FRETS-VWF73 can be easily used with a 96-well format in commercial plate readers.)
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- HY-W015450
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Endogenous Metabolite
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Others
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D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase. D-Ala-D-Ala is a bacterial endogenous metabolite .
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- HY-P5525
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Autocamtide-3 Derived Inhibitory peptide
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CaMK
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Others
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AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)
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- HY-120833
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Caspase
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Others
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Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
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- HY-P10172
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- HY-P5272
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Bacterial
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Inflammation/Immunology
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Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
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- HY-P2089
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MMP
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Others
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Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .
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- HY-P2536
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- HY-P1986
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Caspase
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Cancer
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Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
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- HY-16707
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Z-Ile-Glu-Pro-Phe-Ome
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Peptides
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Inflammation/Immunology
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CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac chymase inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC50 value of 49 µM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC50 value of 4.8 µM .
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- HY-P4899
-
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Beta-secretase
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Neurological Disease
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RE (EDANS) EVNLDAEFK (DABCYL) R is an EDANS and DABCYL double-labeled peptide,serves as a fluorescent substrate for BACE1(Em=360nm,Ex=528nm). RE (EDANS) EVNLDAEFK (DABCYL) R can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction .
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- HY-P1173
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Myristoylated L 803; GSK-3β Inhibitor XIII
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GSK-3
Amyloid-β
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Neurological Disease
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L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .
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- HY-W007599
-
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Peptides
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Cancer
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(S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid is a polypeptide derivative, can be used to synthesis multifunctional amphiphilic peptide dendrimer, as a nonviral gene vectors, realizes the method in cancer research. (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid also involves in the synthesis of an organic substance that increases the luminescence intensity of alkaline phosphatase substrates .
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- HY-P3214
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MLCK(11-19) amide
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Peptides
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Cancer
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Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. Myosin light chain kinase fragment 11-19 amide inhibits hypotonicity-induced Ca 2+ entry. Myosin light chain kinase fragment 11-19 amide can be used in the research of human cervical cancer .
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- HY-P2185
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MMP
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Others
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NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
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- HY-P2185A
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MMP
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Others
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NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
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- HY-P4919
-
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Beta-secretase
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Others
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Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
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- HY-P6023
-
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Factor Xa
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Cardiovascular Disease
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D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity .
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- HY-P6023B
-
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Factor Xa
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Cardiovascular Disease
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D-Leu-Pro-Arg-Rh110-D-Pro acetate is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro acetate consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro acetate can be used to detect FXIa activity .
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- HY-P6023A
-
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Factor Xa
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Cardiovascular Disease
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D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro TFA consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro TFA can be used to detect FXIa activity .
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- HY-P5380
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MMP
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Others
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TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-W027544S
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(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].
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-
-
- HY-W027544S1
-
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(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Cat. No. |
Product Name |
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Classification |
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- HY-145934
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UDP-N-azidoacetylgalactosamine disodium
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Azide
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UDP-GalNAz disodium (UDP-N-azidoacetylgalactosamine disodium) is the analogue of UDP-GalNAc. UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor . UDP-GalNAz (disodium) is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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-
- HY-W027544S1
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5-(Dimethyl-d6-amino)-N-(prop-2-ynyl)naphthalene-1-sulfonamide
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Alkynes
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(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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